Immunohistochemical identification of cells expressing ATP-gated cation channels (P2X receptors) in the adult rat thyroid

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Immunohistochemical identification of cells expressing ATP-gated cation channels (P2X receptors) in the adult rat thyroid.

We carried out immunohistochemistry and western blotting of fresh frozen sections and crude extracts from adult rat thyroids. The histochemical and immunoblotting studies were performed with P2X receptor antibodies from 2 different sources. P2X-immunopositive cells were identified by fluorescence double labelling and confocal microscopy. Results of the western blotting experiments showed double...

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ATP-gated P2X cation-channels.

P2X receptors are ATP-gated cation channels with important roles in diverse pathophysiological processes. Substantial progress has been made in the last few years with the discovery of both subunit selective antagonists and modulators. The purpose of this brief review is to summarize the advances in the pharmacology of P2X receptors, with key properties presented in an easy to access format. Li...

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ATP-gated P2X channels

What are they? P2X channels are a family of cell-membrane cation channels which open within milliseconds of binding ATP. They are distinct from the other family of ATP receptors, the G-proteincoupled P2Y receptors, and also from other transmitter-gated ion channels. P2X channels are the third major family of mammalian transmitter-gated ion channels (Figure 1); they are similar in topology to am...

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ATP-gated P2X receptors in health and disease

1 Division of Biosciences, Autonomic Neuroscience Centre, University College Medical School, London, UK 2 Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, VIC, Australia 3 Neuroscience Department, International School for Advanced Studies (SISSA), Trieste, Italy 4 Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles...

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Architectural and functional similarities between trimeric ATP-gated P2X receptors and acid-sensing ion channels.

ATP-gated P2X receptors and acid-sensing ion channels are two distinct ligand-gated ion channels that assemble into trimers. They are involved in many important physiological functions such as pain sensation and are recognized as important therapeutic targets. They have unrelated primary structures and respond to different ligands (ATP and protons) and are thus considered as two different ion c...

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ژورنال

عنوان ژورنال: Journal of Anatomy

سال: 2001

ISSN: 0021-8782

DOI: 10.1046/j.1469-7580.2001.19850569.x